Antiviral Activity of Nucleoside Analogues against SARS-coronavirus (SARS-CoV)
نویسندگان
چکیده
منابع مشابه
Antiviral activity of nucleoside analogues against norovirus.
BACKGROUND Norovirus (NoV) is the leading cause of epidemic gastroenteritis worldwide. The lack of a cell culture has significantly hampered the development of effective therapies against human NoV. Clinically approved nucleoside and non-nucleoside analogues have been used successfully against RNA viruses. METHODS In this study, we evaluated the efficacy of four nucleoside analogues (2'-C-MeC...
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Three peptides, D1 (amino acid residues 175-201), D2 (a.a. 434-467), and TM (a.a. 1128-1159), corresponding to the spike protein (S) of severe acute respiratory syndrome corona virus (SARS CoV) were synthesized and their immunological functions were investigated in three different animals models (mice, guinea pigs, and rabbits). The peptides mixture formulated either with Freund's adjuvant or s...
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We developed a set of three real-time reverse transcription-polymerase chain reaction (PCR) assays that amplify three different regions of the SARS-associated coronavirus (SARS-CoV), can be run in parallel or in a single tube, and can detect <10 genome equivalents of SARS-CoV. The assays consider all currently available SARS-CoV sequences and are optimized for two prominent real-time PCR platfo...
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ژورنال
عنوان ژورنال: Antiviral Chemistry and Chemotherapy
سال: 2006
ISSN: 2040-2066,2040-2066
DOI: 10.1177/095632020601700506